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Home Nutrigenetic Profile
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Nutrigenetic Profile

What do we offer?

  • icono de laboratorioDetection of genes involved in predisposition to : Cardiometabolic syndrome - Diabetes mellitus type 2 - Overweight + Intake control + Calories burn
  • icono de asesoramiento facultativoCounselling by a specialist before and after the analysis
  • icono de la muestraSample type: Collection of saliva through an oral swab
  • icono de tiempoResults in: 21 days*
  • 590 **
  • * Labour days counting from reception of the sample at the laboratory.
    ** Shipping charges included in peninsular Spain. Not included in Islands.

elige tu test genético

Why should you request this service?

What is the purpose of this analysis?

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  • To help you discover the genetic burden of these common multifactorial diseases and allow you to make the link with environmental factors.

  • To know the mechanisms responsible for obesity, diabetes or cardiovascular disease for each case in order to prescribe personalized treatment.

  • So that you can take preventive measures to protect yourself and your family in case of risk.

Should you do it?

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  • You have a family history.

  • You suffer from OBESITY

  • You suffer from DIABETES:

    • You have difficulty metabolizing carbohydrates.

    • You have high levels of glucose, insulin or glycosylated hemoglobin.

    • Carbohydrates make you gain weight easily.

    • You suffer from obesity (mainly abdominal obesity) and you want to avoid the development of diabetes.

  • You suffer from CARDIOMETABOLIC syndrome

  • You want to improve your lifestyle.

How does it work?

  1. elige tu test genético
    Choose your analysis and a healthcare professional will contact you in 48 hours
  2. frotis bucal para análisis
    You will receive a sample collector kit at home that will be picked up by a courier
  3. instrucciones de uso
    One of our partner labs will proceed to make the analysis
  4. instrucciones de uso
    Your healthcare professional will present your results by videoconference
go further

To go further:


Subtitles available in both English and French

Do you need more information?

  • What are the genes studied and what does it mean?>
      GEN OMIM or reference FONCTION RELATED DISEASE AND GENE TYPE
      MC4R 155541
      601665
      It is related to eating behavior because it reduces satiety and increases appetite, which promotes overweight and obesity OBESITY AND DIABETES :ECONOMIC GENES
      FTO 610966 It reduces satiety and increases appetite for high-calorie foods such as fats and sugars. It also lowers the production of heat of the body, thus promoting the storage of energy in the form of fat
      BDNF 113505
      607499
      It promotes the storage of fat in stressful situations, it is found more frequently in women.
      UCP1 113730 It regulates the action thyroid hormone responsible for burning calories in the form of heat, although at rest this pendant unites physical activity. If this function is slowed down, the body accumulates fat.
      UCP3 602044 It is involved in the production of heat through the thyroid hormone and also plays a role in the burning of calories on physical activity. These are malfunctions that promote overweight and obesity
      ADRB2 109690
      601665
      It regulates the response of the body to stress by translating it into a feeling of hunger and responds by storing energy in the form of fat.
      ADRB3 109691 It responds to stress by interpreting it as hunger, which promotes overweight and obesity. It is also associated with insulin resistance and metabolic syndrome. This gene has its effects multiplied in the presence of the gene UCP1.
      PPARG 601487 The ancestral gene is not suitable for contemporary foods such as refined foods (flours and sugars) or processed and saturated fats that promote fat formation and insulin resistance. This gene also complicates the burning of calories. In addition, this gene is the main target of one of the antidiabetic drugs, a good knowledge of this gene allows a personalized treatment
      ACE 106180 This gene regulates blood pressure through the level of sodium in the kidneys and also promotes fat formation, so salt intake not only promotes hypertension, it also causes overweight and obesity.
      IL1B 147720 It promotes chronic inflammation and, associated with the action of the next gene, is directly related to the control of body fat especially in young people. It acts on the regulation of fat formation, the control of intake and energy expenditure and therefore on the impact of obesity.
      IL1RN 147679 It modifies the function of the immune system, promoting inflammation of fat, this being closely related to the development of obesity. Its action is reinforced by that of the previous gene, increasing the amount of total fat.
      IL6 147620 It causes a chronic low-grade inflammation of adipose tissue, induces insulin resistance because it alters its receptor and promotes the development of type 2 diabetes (adult).
      TNFa 191160 It promotes inflammation of the fatty tissue and modifies the insulin receptor and leptitis, causing resistance to these hormones due to the dysfunction of its receptor.
      FABP2 134640 It allows a better absorption of dietary fat in the intestine and alters its oxidation, promoting insulin resistance and increasing the risk of atherosclerosis
      ADIPOQ 605441 It induces insulin resistance that hinders carbohydrate metabolism and promotes the development of obesity and type 2 diabetes.
      IRS1 147545 It causes insulin resistance and therefore a high risk of diabetes because it directly affects the insulin receptor.
      FABP2 134640 It facilitates the absorption of dietary fat in the intestine and alters its oxidation, promoting insulin resistance and increasing the risk of atherosclerosis. CARDIOVASCULARY RISKS: ECONOMIC GENES
      APOE 107741 It slows the elimination of fats from food ingested in the blood, causing atherosclerosis and secondary vascular disease.
      NOS3 163729 It slows the elimination of fats from food ingested in the blood, causing atherosclerosis and secondary vascular disease.
      MTHFR 607093
      188050
      It regulates the levels of folic acid (one of the B vitamins), since the deficiency of this nutrient causes thrombosis, vascular embolism and cardiovascular diseases.
      ACE 106180 This gene regulates blood pressure through the level of sodium in the kidneys and also promotes fat formation, so salt intake not only promotes hypertension, it also causes overweight and obesity.
      SERPINE1 173360 This gene regulates blood pressure through the level of sodium in the kidneys and also promotes fat formation, so salt intake not only promotes hypertension, it also causes overweight and obesity.
  • How to interpret the results?>

      Twenty-four genes associated with cardiometabolic syndrome and involved in nutritional response are analyzed. The polymorphisms analyzed are variants of normality, so the result of this study should not be considered as a diagnosis, but rather as an indicator of genetic risk. The results obtained can be interpreted as follows:

      elige tu test genético

      The genes analyzed are distributed in the report according to their pathophysiological processes:

      • GROUP I: Genes involved in the central control of the input
      • GROUP II: Genes associated with the regulation of thermogenesis
      • GROUP III: Genes related to pro-inflammatory processes in adipose tissue
      • GROUP IV: Genes involved in the development of insulin resistance
      • GROUP V: Genes Associated with Cardiovascular and Cardiometabolic Risk
      • GROUP VI: Complementary analyzes: genetic study of Celiac disease, lactose intolerance and fructose intolerance
  • Sensitivity and Specificity>

      The analysis of this gene is carried out using the PCR (Polymerase Chain Reaction) technique and reaction products are studied by reverse hybridization with specific sequence probes (SSOP). Moreover, the results are studied by direct sequencing and subsequent capillary electrophoresis. These molecular biology techniques are commonly used in the field of molecular genetics and exhibit high sensitivity and specificity when using specific primers for each analyzed polymorphism. The reliability of our genetic studies is close to 100%, we apply quality processes certified by competent national and international organizations.

  • Guidelines>
    • Aranceta-Bartrina, J., et al. Prevalencia de obesidad general y obesidad abdominal en la población adulta española (25–64 años) 2014–2015: estudio ENPE. Rev Esp Cardiol. 2016;69:579-87 - Vol. 69 Núm.06 DOI: 10.1016/j.recesp.2016.02.010
    • Strandberg,L., et al.; Interleukin-1 System Gene Polymorphisms Are Associated with Fat Mass in Young Men, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 7, 1 July 2006, Pages 2749–2754, https://doi.org/10.1210/jc.2005-2786
    • Corica, F., et al.; Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects. Int J Obes Relat Metab Disord. 1999 Apr;23(4):355-60
    • German JB. et al.: Nutrigenomics and Personalized Diets: What Will They Mean for Food? Annu Rev Food Sci Technol. 2011 ; 2: 97–123. doi:10.1146/annurev.food.102308.124147
    • Grimaldi KA. et al.; Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice. Genes & Nutrition (2017) 12:35 DOI 10.1186/s12263-017-0584-0
    • Rescigno T. et al.; Bioactive Nutrients and Nutrigenomics in Age-Related Diseases. Molecules 2017, 22, 105; doi:10.3390/molecules22010105
    • Hetherington y Cecil, 2010. Gene-environment interactions in obesity. Forum Nutr 63: 195-203.
    • Loos et al, 2008. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40(6): 768-775.
    • Buzzetti et al, 2004. The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity. Eur J Hum Genet 12(12):1050-4.
    • de Oliveira et al, 2015. ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction. Diabetology & Metabolic Syndrome 7:34-43.
    • Stephens et al, 2007. Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus. Mol Genet Metab 90(4):422-8.
    • Online Mendelian Inheritance in Man, OMIM®. McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), {24/04/2018}. World Wide Web URL: https://omim.org/

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