Advances in predictive medicine


I want to start this article by explaining what predictive medicine is for me: it is the medicine that allows us not to get sick and that if we do, it is as mild as possible.


There are many small acts of predictive medicine that we do every day. In my case: getting a flu shot, going for a run or 10K walk every day and warming up before doing it and not smoking are simple examples of how to improve my own health or at least not make it worse.


But you have to be careful with everything you read about improving our health, especially on the internet, because not everything that is published is true and there are many hoaxes that can worsen our health instead of improving it.


Apart from the above there is another important aspect of predictive medicine: genetics. At least 20% of our health depends on genetics and this is a very important percentage (at least one fifth).


2 years ago I weighed 141 kg, that is, I was obese, which increased the probability of having cardiovascular diseases, diabetes, some types of cancer, etc. and after trying to lose weight in many ways (some of them not very healthy, I must admit) in the end I ended up recovering more weight (and volume) than the one I lost (the famous rebound effect), which already indicated that some genetic problem could to have. After performing a nutrigenetic profile and putting myself in the hands of a nutritionist, I have lost 57 kilos and managed not to regain the lost weight.


Now, thanks to knowing my genetics, I can make informed decisions with my nutrition so as not to gain visceral fat again and be well nourished.


Knowing our genome will allow us to know the probability of having certain diseases and act accordingly. Little by little, new studies are coming out that will allow us to act better on our health and anticipate future diseases or improve our quality of life.


As a sign that every day we know more about our genes and that we know how to act accordingly with our own genetics, I share with you some studies and articles that have been published recently that will help us improve our health if we know our genetics:


Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five-country cohort study.

Inferring fetal fractions from read heterozygosity enhances non-invasive prenatal screening.

CDKN2A testing and genetic counseling promote reductions in objectively measured sun exposure one year later.


Calculation of genetic risk for obesity: Polygenic prediction of weight and obesity trajectories from birth to adulthood.


Getting to the core of autism.


A specific CNOT1 mutation results in a novel syndrome of pancreatic agenesis and holoprosencephaly through impaired pancreatic and neurological development.


Epigenetics in human obesity and type 2 diabetes.


Maternal and fetal genetic effects on birth weight and its relevance to cardiometabolic risk factors.


Identified a mechanism by which the LRRK2 gene contributes to the development of Parkinson’s disease that could be used as a target for the treatment of the disease.


The current state of genetics and the state of the art of information technologies allow us to have our genome sequenced and to know the probability of having certain diseases and how you can fight against them so that they do not develop or minimize their severity.


But it also allows us to store said genome to be able to apply the new studies and investigations that are being carried out, whenever the owner of said genome so wishes, and in this way people with the sequenced genome can have their genetic predispositions updated and possible treatments with the latest scientific advances.


Those medmesafe users who have carried out a study through our platform can request other services using the above sequencing by contacting us by phone 911 284 591 or by email informacion@medmesafe.com.


Soon we will have on our platform genetic services based on exome (all those genes that we know how to interpret today) or on the complete genome, which will allow us to store the sequencing to carry out new studies and analyzes or to update those already carried out with the latest research We will inform you on social networks.


Carlos Martín, CTO of medmesafe


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Project manager of the architecture service in SEPE Central Services - Procesia WEB and API architecture service coordinator - INECO Former CTO - medmesafe