This site uses both its own cookies and third-party cookies in order to obtain statistical data on the browsing activity of its users. You accept these cookies by continuing to browse the Portal or by clicking ACCEPT You can find information on how to enable/disable browser cookies reading our Cookie Policy

This site uses both its own cookies and third-party cookies (files which are installed on the user’s device and which record browsing information) in order to obtain statistical data on the browsing activity of its users. By clicking ACCEPT or by continuing to browse the Portal, you accept that PROMETUM SPAIN S.L.U. may store and use these cookies. To find out more, please read our Cookie Policy where you can also find information on how to enable/disable browser cookies. ACCEPT

You will receive an e-mail with instructions to reset your password
Home BRCA - Breast cancer
icono oncologia.png

BRCA - Breast cancer

What do we offer?

  • icono de laboratorioDetection of genes involved in predisposition to cancer: Breast and other related cancers: Pancreatic, Prostate
  • icono de asesoramiento facultativoCounselling by a specialist before and after the analysis
  • icono de la muestraSample type: Collection of saliva through an oral swab
  • icono de tiempoResults in: 30 days*
  • 550 **
  • * Labour days counting from reception of the sample at the laboratory.
    ** Shipping charges included in peninsular Spain. Not included in Islands.

elige tu test genético

Why should you request this service?

What is the purpose of this analysis?

  • To detect if your DNA predisposes you to suffer this cancer.

  • If you suffer from a cancer, to detect if it will be pass on to your offspring and to customize your treatment.

Should you do it?

  • If any of these premises happen:

    • Family background on cancer diagnosed before age 50.
    • Family background on male breast cancer at any age.
    • Family background on breast and ovarian cancer in the same person.
    • 2 or more cases of breast and/or ovarian cancer in the same family line.
    • amily background on bilateral breast cancer with one of the tumors being diagnosed before age 50.
    • 3 or more cases of breast, endometrium or thyroid cancer at the same family line.
    • Background on triple-negative breast cancer before age 60.

How does it work?

  1. elige tu test genético
    Choose your analysis and a healthcare professional will contact you in 48 hours.
  2. frotis bucal para análisis
    Receive a sample collector kit at home that will be picked up by a courier.
  3. instrucciones de uso
    One of our partner labs makes the analysis.
  4. instrucciones de uso
    Your healthcare professional presents your results by videoconference.
go further

To go further:

Subtitles available in both English and French

Do you need more information?

  • What are the genes studied and what does it mean?>
      BRCA1 113705
      Breast cancer
      Ovarian cancer
      Other 81%; 63%
      BRCA2 600185
      Breast cancer
      Ovarian cancer
      Other 84%; 27%
  • How to interpret the results?>
      A mutation has been identified in a gene, which results in greater susceptibility to the disease. NO mutation has been identified in the gene, so there is less risk that the patient will contract the disease. A genetic variant whose meaning is currently unknown has been identified.
      Increased risk Moderate risk Moderate risk but the patient must be monitored
  • Sensitivity and Specificity>

      These genes are analyzed by NGS techniques in combination with conventional approaches to molecular genetics when necessary. With this analysis, it is possible to detect point mutations in exons, in deep intronic regions (up to 45bp), in the untranslated regulatory regions of breast cancer-associated genes, as well as in some structural variants.
      However, this examination has some limitations, it is mainly known to present a high sensitivity and specificity (> 99%) as to the variations of simple nucleotides and small indels up to 9 nucleotides. Structural variants that affect only one exon present in coding exon genes may not be detected. For the rest of the major structural variants, the detection rate can reach up to 95%.

  • Guidelines>
    • Asociación Española Contra el Cáncer:
    • Castera L, et al. Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes. Eur J Hum Genet. 2014. 22(11):1305-13.

    • Walsh T, et al. Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. Proc Natl Acad Sci U S A. 2010. 107(28):12629-33.
    • Van der Groep PE, et al. Pathology of hereditary breast cancer. Cell Oncol (Dordr). 2011. 34(2):71-88.
5. Riesgo máximo acumulado de desarrollar un tumor a lo largo de la vida de los portadores de mutaciones patogénicas.
    • Levy-Lahad E, Friedman E. Cancer risks among BRCA1 and BRCA2 mutation carriers. British Journal of Cancer 2007; 96(1):11–15
    • National Cancer Institute website. BRCA and BRCA2: Cancer Risk and Genetic Testing. Accessed March 7, 2018.
    • Online Mendelian Inheritance in Man, OMIM®. McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), {24/04/2018}. World Wide Web URL:

Any questions?

Enter the verification code to continue

In compliance with the requirements of REGULATION (EU) 2016 / 679 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 27 april 2016 on the protection of individuals with regard to the processing of personal data and the free movement of such data and repealing directive 95 / 46 / ec (general regulation of data protection), you are informed that ...