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Cardiometabolic

elige tu test genético

What do we offer?

  • icono de laboratorioDetection of genes involved in predisposition to : Cardiometabolic syndrome - Diabetes mellitus type 2
  • icono de asesoramiento facultativoCounselling by a specialist before and after the analysis
  • icono de la muestraSample type: Collection of saliva through an oral swab
  • icono de tiempoResults in: 14 days*
  • 335 **
  • * Labour days counting from reception of the sample at the laboratory.
    ** Shipping charges included in peninsular Spain. Not included in Islands.

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More information: +34 911 284 591
elige tu test genético
Purchase
More information: +34 911 284 591

Why should you request this service?

What is the purpose of this analysis?

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  • To help you discover the genetic burden of these common multifactorial diseases and relate them to your environmental factors.

  • To learn more about the mechanisms responsible for obesity, diabetes and, cardiovascular diseases while offering adapted and personalized treatments.

  • To proactively protect yourself and your family from risk.

Should you do it?

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  • You have a family history of cardiometabolic syndrome

  • You suffer from cardiometabolic syndrome

    • You have abdominal obesity with or without metabolic syndrome.

    • You have the metabolic syndrome: hypertension, dyslipidemia (high cholesterol or triglycerides). High uric acid, heart disease (heart attack, angina pectoris) and / or cerebrovascular accident, ischemia, etc.

    • Fatty liver.

    • You have high blood pressure or isolated atherosclerosis.

    • You have one or more members in your family who have had high blood pressure or atherosclerosis.

    • Sleep apnea (use of CEPAP type machines).

  • You want to improve your lifestyle and avoid diseases development.

Purchase
More information: +34 911 284 591
Purchase
More information: +34 911 284 591

How does it work?

  1. elige tu test genético
    Select desired analysis and a specialist, then you have a video-consultation.
  2. frotis bucal para análisis
    Receive a sample collector kit at home that will be picked up by a courier.
  3. instrucciones de uso
    One of our partner labs makes the analysis.
  4. instrucciones de uso
    Your healthcare professional presents your results via videoconference.
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Subtitles available in both English and French
More information: +34 911 284 591
More information: +34 911 284 591

additional information

  • What are the genes studied and what does it mean?
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      GEN OMIM or reference FUNCTION RELATED DISEASE AND GENE TYPE
      PPARG 601487 The ancestral gene is not suitable for contemporary foods such as refined foods (flours and sugars) or processed and saturated fats that promote fat formation and insulin resistance. This gene also complicates the burning of calories. In addition, this gene is the main target of one of the antidiabetic drugs, a good knowledge of this gene allows a personalized treatment CARDIOMETABOLIC SYNDROME: ECONOMIC GENES
      FABP2 134640 It allows a better absorption of dietary fat in the intestine and alters its oxidation, promoting insulin resistance and increasing the risk of atherosclerosis.
      IRS1 147545 It causes insulin resistance and therefore a high risk of diabetes because it directly affects the insulin receptor.
      APOE 107741 It slows the elimination of fats from food ingested in the blood, causing atherosclerosis and secondary vascular disease
      NOS3 163729 It slows the elimination of fats from food ingested in the blood, causing atherosclerosis and secondary vascular disease
      MTHFR 607093
      188050
      It regulates the levels of folic acid (one of the B vitamins), since the deficiency of this nutrient causes thrombosis, vascular embolism and cardiovascular diseases.
      ACE 106180 This gene regulates blood pressure through the level of sodium in the kidneys and also promotes fat formation, so salt intake not only promotes hypertension, it also causes overweight and obesity.
      SERPINE1 173360 It is associated with two mechanisms that promote the development of acute myocardial infarction: the formation of atherosclerotic plaques and the weakening of clot destruction mechanisms.
  • How to interpret the results?
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      Ten genes associated with the cardiometabolic syndrome and involved in the nutritional response of the patient are analyzed.

      • Genes involved in the development of insulin resistance
      • Genes associated with cardiovascular and cardiometabolic risk

      The polymorphisms analyzed are variants of normality, so the result of this study should not be considered as a diagnosis, but rather as an indicator of genetic risk. The results obtained in the patient can be interpreted as follows:

      The report details the genotype detected for each gene, as well as its medical interpretation. The results are accompanied by personalized recommendations according to the genetic results
  • Sensitivity and Specificity
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      The analysis of this gene is carried out using the PCR (Polymerase Chain Reaction) technique. Moreover, the results are studied by direct sequencing and subsequent capillary electrophoresis. These molecular biology techniques are commonly used in the field of molecular genetics and exhibit high sensitivity and specificity when using specific primers for each analyzed polymorphism. The reliability of our genetic studies is close to 100%, we apply quality processes certified by competent national and international organizations.

  • Sources
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    • Guallar-Castillón, P., et al. Magnitud y manejo del síndrome metabólico en España en 2008-2010: Estudio ENRICA. Revista Española de Cardiología,Volume 67, Issue 5,2014,Pages 367-373,ISSN 0300-8932, https://doi.org/10.1016/j.recesp.2013.08.014
    • Aranceta-Bartrina, J., et al. Prevalencia de obesidad general y obesidad abdominal en la población adulta española (25–64 años) 2014–2015: estudio ENPE. Rev Esp Cardiol. 2016; 69:579-87 - Vol. 69 Núm.06 DOI: 10.1016/j.recesp.2016.02.010
    • Corica, F., et al.; Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects. Int J Obes Relat Metab Disord. 1999 Apr;23(4):355-60.
    • German JB. et al.: Nutrigenomics and Personalized Diets: What Will They Mean for Food? Annu Rev Food Sci Technol. 2011 ; 2: 97–123. doi:10.1146/annurev.food.102308.124147.
    • Grimaldi KA. et al.; Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice. Genes & Nutrition (2017) 12:35 DOI 10.1186/s12263-017-0584-0
    • Rescigno T. et al.; Bioactive Nutrients and Nutrigenomics in Age-Related Diseases. Molecules 2017, 22, 105; doi:10.3390/molecules22010105
    • de Oliveira et al, 2015. ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction. Diabetology & Metabolic Syndrome 7:34-43.
    • Stephens et al, 2007. Association between plasma IL-6, the IL6 -174G>C gene variant and the metabolic syndrome in type 2 diabetes mellitus. Mol Genet Metab 90(4):422-8.
    • Online Mendelian Inheritance in Man, OMIM®. McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), {24/04/2018}. World Wide Web URL: https://omim.org/
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More information: +34 911 284 591
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More information: +34 911 284 591

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