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elige tu test genético

What do we offer?

  • icono de laboratorioDetection of genes involved in predisposition to : Osteoporosis
  • icono de asesoramiento facultativoCounselling by a specialist before and after the analysis
  • icono de la muestraSample type: Collection of saliva through an oral swab
  • icono de tiempoResults in: 14 days*
  • 260 **
  • * Labour days counting from reception of the sample at the laboratory.
    ** Shipping charges included in peninsular Spain. Not included in Islands.

elige tu test genético

Why should you request this service?

What is the purpose of this analysis?

  • To make you aware of the risk of contracting osteoporosis, thus preventing the appearance of symptoms by modifying environmental factors (diet, food supplements, regular physical activity ...)

Should you do it?

  • You are a woman over 20-25 years old.

  • You are a man over 70 years of age and, in case of risk factors, from the age of 50 years.

How does it work?

  1. elige tu test genético
    Select desired analysis and a specialist, then you have a video-consultation.
  2. frotis bucal para análisis
    Receive a sample collector kit at home that will be picked up by a courier.
  3. instrucciones de uso
    One of our partner labs makes the analysis.
  4. instrucciones de uso
    Your healthcare professional presents your results via videoconference.
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To go further:

Subtitles available in both English and French

additional information

  • What are the genes studied and what does it mean?
      COL1A1 120150
      Osteoporosis Osteogenesis imperfect, type I, II, III, IV
      Osteoporosis associated with bone mineral density
      ESR1 133430
      Osteoporosis Variation of bone mineral density
      VDR 601769
      Osteoporosis Involutive osteoporosis
  • How to interpret the results?
      Gene COL1A1: SNP IVS1-440G>T
      Gene ESR1: SNP IVS1-351A>G
      Gene VDR: SNP IVS10+283G>A
      No genetic variants predisposing to the disease have been detected.
      Increased risk Moderate risk
      The report is accompanied by recommendations from the Foundation for Osteoporosis and Metabolic Bone Diseases (FHOEMO) and the Spanish Association Against Osteoporosis (AECOS).
  • Sensitivity and Specificity

      The analysis of this gene is carried out using the PCR (Polymerase Chain Reaction) technique. Moreover, the results are studied by direct sequencing and subsequent capillary electrophoresis. These molecular biology techniques are commonly used in the field of molecular genetics and exhibit high sensitivity and specificity when using specific primers for each analyzed polymorphism. The reliability of our genetic studies is close to 100%, we apply quality processes certified by competent national and international organizations.

  • Sources
    • Adler R. Osteoporosis in men: a review. Bone Research 2014; 2:14001; doi:10.1038/boneres.2014,1.
    • Khosla, S. (2010). Update in Male Osteoporosis. The Journal of Clinical Endocrinology and Metabolism, 95(1), 3–10.
    • Uitterlinden, A. G., et al. Relation of alleles of the collagen type I-alpha-1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. New Eng. J. Med. 338: 1016-1021, 1998.
    • Garnero, P., et al. Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density. J. Clin. Endocr. Metab. 90: 4829-4835, 2005.
    • Becherini, L., et al. Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor-alpha gene and their relationship to bone mass variation in postmenopausal Italian women. Hum. Molec. Genet. 9: 2043-2050, 2000.
    • Uitterlinden, A. et al.; The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis. Ann Intern Med. 2006;145:255-264.
    • Online Mendelian Inheritance in Man, OMIM®. McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), {24/04/2018}. World Wide Web URL:

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