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Hypertension Risk

elige tu test genético

What do we offer?

  • icono de laboratorioDetection of genes involved in predisposition to : Arterial hypertension
  • icono de asesoramiento facultativoCounselling by a specialist before and after the analysis
  • icono de la muestraSample type: Collection of saliva through an oral swab
  • icono de tiempoResults in: 14 days*
  • 330 **
  • * Labour days counting from reception of the sample at the laboratory.
    ** Shipping charges included in peninsular Spain. Not included in Islands.

Purchase
More information: +34 911 284 591
elige tu test genético
Purchase
More information: +34 911 284 591

Why should you request this service?

What is the purpose of this analysis?

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  • To make you aware of the risk of hypertension, thus preventing the appearance of symptoms by changing environmental factors and at the same time minimizing the risk of developing associated pathologies in the kidneys, brain or heart.

  • To raise awareness of a potential genetic predisposition for hypertension and to minimize the risk of developing the disease.

Should you do it?

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  • You have a family history of hypertension.

Purchase
More information: +34 911 284 591
Purchase
More information: +34 911 284 591

How does it work?

  1. elige tu test genético
    Select desired analysis and a healthcare professional will contact you within 48 hours.
  2. frotis bucal para análisis
    Receive a sample collector kit at home that will be picked up by a courier.
  3. instrucciones de uso
    One of our partner labs will make the analysis.
  4. instrucciones de uso
    Your healthcare professional will present your results via videoconference.
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To go further:


Subtitles available in both English and French
More information: +34 911 284 591
More information: +34 911 284 591

additional information

  • What are the genes studied and what does it mean?
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      GENE OMIM or reference RELATED DISEASE SYNDROME
      ACE 106180 Coronary artery disease. Cardiovascular pathologies Risk of acute myocardial infarction
      Risk of hypertension
      Coronary changes
      ADRB2 109690 Metabolic syndrome
      Risk of hypertension
      GNB3 139130145500 Risk of progression to more severe hypertension
      NOS3 163729 Preeclampsia, coronary heart disease Risk of hypertension
  • How to interpret the results?
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      POSITIVE NEGATIVE
      A genetic variant predisposing to the disease has been detected: No genetic variants predisposing to the disease have been detected.
      Increased risk Moderate risk
  • Sensitivity and Specificity
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      The analysis of this gene is carried out using the PCR (Polymerase Chain Reaction) technique. Moreover, the results are studied by direct sequencing and subsequent capillary electrophoresis. These molecular biology techniques are commonly used in the field of molecular genetics and exhibit high sensitivity and specificity when using specific primers for each analyzed polymorphism. The reliability of our genetic studies is close to 100%, we apply quality processes certified by competent national and international organizations.

  • Sources
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    • Saeed Mahmood, M, et al. Association of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with essential hypertension. J Hum Hypertens. 2003 Oct;17(10):719-23. OI:10.1038/sj.jhh.1001600.
    • Luft FC. Twins in cardiovascular genetic research. Hypertension. 2001 Feb;37(2 Pt 2):350-6.
    • Rudnicki M1, Mayer G. Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renaldisease. Pharmacogenomics. 2009 Mar;10(3):463-76.
    • Seidlerová J, Filipovský J, Mayer O Jr, Kučerová A, Pešta M. Association between endothelial NO synthase polymorphisms and arterial properties in the general population. Nitric Oxide. 2015 Jan 30;44:47-51
    • Vecoli C. Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease. Vitam Horm. 2014;96:387-406
    • Takeuchi F, Yamamoto K, Katsuya T, Sugiyama T, Nabika T, Ohnaka K, Yamaguchi S, Takayanagi R, Ogihara T, Kato N. Reevaluation of the association of seven candidate genes with blood pressure and hypertension: a replication study and meta-analysis with a larger sample size. Hypertens Res. 2012 Aug;35(8):825-31
    • Hager A, Bildau J, Kreuder J, Kaemmerer H, Hess J. Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair. Int J Cardiol. 2011 Aug 18;151(1):63-8.
    • Guo X, Cheng S, Taylor KD, Cui J, Hughes R, Quiñones MJ, Bulnes-Enriquez I, De la Rosa R, Aurea G, Yang H, Hsueh W, Rotter JI. Hypertension genes are genetic markers for insulin sensitivity and resistance. Hypertension. 2005 Apr;45(4):799-803.
    • Online Mendelian Inheritance in Man, OMIM®. McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), {24/04/2018}. World Wide Web URL: https://omim.org/
Purchase
More information: +34 911 284 591
Purchase
More information: +34 911 284 591

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