Thromboembolism Risk

elige tu test genético

What do we offer?

  • icono de laboratorioDetection of genes involved in predisposition to : Thromboembolism
  • icono de asesoramiento facultativoCounselling by a specialist before and after the analysis
  • icono de la muestraSample type: Collection of saliva through an oral swab
  • icono de tiempoResults in: 14 days*
  • 390 **
  • * Labour days counting from reception of the sample at the laboratory.
    ** Shipping charges included in peninsular Spain. Not included in Islands.

More information: +34 911 284 591
elige tu test genético
More information: +34 911 284 591

Why should you request this service?

What is the purpose of this analysis?

  • To indicate your risk of developing venous thrombosis and thus give you the possibility of preventing its development by modifying the environmental component (eating habits, administration of anticoagulants, exercise...).

  • To help you prevent the risk of thrombosis on your family members.

Should you do it?

  • You have a family history of venous thrombosis, arterial thrombosis, embolism, etc.

  • You don’t have any family history:

    • You are taking oral contraceptives.
    • You have had thrombosis during your pregnancy.
    • You have had several abortions.
    • You have children with NTD (neural tube defect).
    • You are pregnant and have IUGR, (intrauterine growth restriction) thrombophlebitis or placental thrombosis.
    • You face prolonged immobility (prolonged postoperative and lower limb pathologies).
    • You have varicose veins.
More information: +34 911 284 591
More information: +34 911 284 591

How does it work?

  1. elige tu test genético
    Select desired analysis and a specialist, then you have a video-consultation.
  2. frotis bucal para análisis
    Receive a sample collector kit at home that will be picked up by a courier.
  3. instrucciones de uso
    One of our partner labs makes the analysis.
  4. instrucciones de uso
    Your healthcare professional presents your results via videoconference.
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To go further:

Subtitles available in both English and French
More information: +34 911 284 591
More information: +34 911 284 591

additional information

  • What are the genes studied and what does it mean?
      F2 176930
      Thrombophilia Risk of thromboembolism
      F5 612309
      Thrombophilia due to resistance to activated protein C Thrombophilia risk due to factor V Leiden
      FGB 134830
      Thrombolia Increased risk of venous thromboembolism and cardiovascular disease
      MTHFR 607093
      Risk of cardiovascular disease and neurodegenerative diseases due to hyperhomocysteinemia Risk of thromboembolism
      SERPINE1 173360
      Thrombophilia Increased risk of thrombotic troubles
  • How to interpret the results?
      Gene F2: MUTATION c.20210G>A
      Gene F5: MUTATION c.1691G>A
      Gene FGB: SNP c.-455G>A (rs1800790)
      Gene MTHFR: MUTATIONS c.677C>T Y c.1298A>C
      Gene SERPINE1 (PAI-1): POLYMORPHISME c.-675_4G/5G
      No genetic variants predisposing to the disease have been detected.
      Increased risk Same risk as random people
  • Sensitivity and Specificity

      The analysis of this gene is carried out using the PCR (Polymerase Chain Reaction) technique. Moreover, the results are studied by direct sequencing and subsequent capillary electrophoresis. These molecular biology techniques are commonly used in the field of molecular genetics and exhibit high sensitivity and specificity when using specific primers for each analyzed polymorphism. The reliability of our genetic studies is close to 100%, we apply quality processes certified by competent national and international organizations.

  • Sources
    • Varga, E. A., et al. Management of inherited thrombophilia: guide for genetics professionals. Clin. Genet. 81: 7-17, 2012.
    • Grimaudo, V., et al. Hypofibrinolysis in patients with a history of idiopathic deep vein thrombosis and/or pulmonary embolism. Thromb Haemost. 1992 Apr 2;67(4):397-401.
    • Gómez C, Lozano S, Alberca S y col: Trombofilias y trombosis venosa profunda. Mapfree Med 2002; 13: 53-62.
    • Uri Seligssohn, Aarón Lubetsky: Genetic susceptibility to venous trombosis. N Engl J Med 2001; 344(16): 1222-31.
    • Simone B y cols. Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls. Eur J Epidemiol. 2013 Aug;28(8):621-47.
    • Segal JB, Brotman DJ, Necochea AJ, Emadi A, Samal L, Wilson LM, Crim MT, Bass EB. Predictive value of factor V Leiden and prothrombin G20210A in adults with venous thromboembolism and in family members of those with a mutation: a systematic review. JAMA. 2009 Jun 17;301(23):2472-85.
    • Wu O1, Robertson L, Twaddle S, Lowe GD, Clark P, Greaves M, Walker ID, Langhorne P, Brenkel I, Regan L, Greer I. Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) study. Health Technol Assess. 2006 Apr;10(11):1-110.
    • Kathiresan S1, Yang Q, Larson MG, Camargo AL, Tofler GH, Hirschhorn JN, Gabriel SB, O'Donnell CJ. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1405-12.
    • Online Mendelian Inheritance in Man, OMIM®. McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), {24/04/2018}. World Wide Web URL: https://omim.org/
More information: +34 911 284 591
More information: +34 911 284 591

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