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Obesity and Diabetes
Learn how genetics influence your diet and your risk of type 2 diabetes.
With this study, your nutritionist will be able to prepare a personalized diet just for you with the
greatest possible guarantee of success. Genes related to your metabolism, the capacity to burn fat,
obesity, type 2 diabetes, inflammation in adipose tissue are analysed to detect your risks
and be able to take preventive measures.
500M
It is estimated estimate that by 2018 there are more than 500 million cases of type 2 diabetes worldwide
and the number will continue to grow in the coming years.(1)
39%
39% of the world's adult population is overweight
and 13% is obese, according to 2016 data.(2)
Obesity
Overweight and obesity are major risk factors
for a number of chronic diseases, including diabetes, cardiovascular diseases and cancer.(3)
+ risk
Obesity is associated with an increased risk of developing multiple types of cancer.
It is estimated that up to 20% of all cancers are caused by obesity.(4)
(1) Source: https://diabetes.diabetesjournals.org/content/67/Supplement_1/202-LB
(2) Source: World health organization
(3) Source: World health organization
(4) Source: Revista española de cardiología
Obesity and Diabetes
- A number of genes related to central intake control, thermogenesis regulation, pro-inflammatory processes in adipose tissue and development of insulin resistance are analyzed.
- A genetic counsellor approved by medmesafe will accompany you before and after the analysis by video consultation.
3 weeks
Spain
Saliva
PCR
- Counting from the reception of the sample in the laboratory.
- Only available in Spain at the moment
- Collection of saliva.
- These genes are analyzed by the PCR multiple amplification technique, and the reaction products are studied by mini-sequencing and subsequent capillary electrophoresis.
- These molecular biology techniques are commonly used in the molecular genetics laboratory and have a high sensitivity and specificity when using specific primers for each polymorphism that is analysed. The reliability of the genetic studies is close to 100%, and in the laboratory we follow all the quality processes, audited by national and international entities.
Nutrigenetics examines how genetic variation affects the response of an organism to a given diet,
evaluating the risks and benefits of specific diets and dietary components and formulating
“personalized nutrition” recommendations
How does it work?
-
Select desired analysis and a specialist, then you have a video-consultation. -
Receive a sample collector kit at home that will be picked up by a courier. -
One of our partner labs makes the analysis. -
Your healthcare professional presents your results via videoconference.
Why should you request this service?
What is this analysis for?
- To know the genetic load of these common multifactorial diseases and to weigh them in relation to environmental factors.
- So that you know the mechanisms that produce obesity, diabetes or cardiovascular disease in each case to provide personalized treatments.
- So that you can apply preventive measures in you or your family in case of risk.
Should you do it?
- If you have a family history:
- You have first-degree parents who suffer from obesity or overweight.
- You have a family history of adult diabetes.
- If you suffer from OBESITY:
- Severe obesity and / or early origin (childhood / adolescence).
- You have been on several diets without losing weight or have observed the yo-yo effect.
- You have eating disorders: satiety or anxiety problems.
- You can't burn calories despite exercising.
- You gain weight despite a healthy lifestyle.
- If you suffer from DIABETES:
- You have difficulty metabolizing carbohydrates.
- You have high levels of glucose, insulin or glycosylated hemoglobin.
- Carbohydrates make you gain weight easily.
- You suffer from obesity (mainly abdominal obesity) and want to prevent the development of diabetes.
- If you want to improve your quality of life.
What are the genes studied and what does it mean?
| GEN | OMIM or reference | FONCTION | RELATED DISEASE AND GENE TYPE |
|---|---|---|---|
| MC4R | 155541 601665 |
It is related to eating behavior because it reduces satiety and increases appetite, which promotes overweight and obesity | OBESITY AND DIABETES :ECONOMIC GENES |
| FTO | 610966 | It reduces satiety and increases appetite for high-calorie foods such as fats and sugars. It also lowers the production of heat of the body, thus promoting the storage of energy in the form of fat | |
| BDNF | 113505 607499 |
It promotes the storage of fat in stressful situations, it is found more frequently in women. | |
| UCP1 | 113730 | It regulates the action thyroid hormone responsible for burning calories in the form of heat, although at rest this pendant unites physical activity. If this function is slowed down, the body accumulates fat. | |
| UCP3 | 602044 | It is involved in the production of heat through the thyroid hormone and also plays a role in the burning of calories on physical activity. These are malfunctions that promote overweight and obesity | |
| ADRB2 | 109690 601665 |
It regulates the response of the body to stress by translating it into a feeling of hunger and responds by storing energy in the form of fat. | |
| ADRB3 | 109691 | It responds to stress by interpreting it as hunger, which promotes overweight and obesity. It is also associated with insulin resistance and metabolic syndrome. This gene has its effects multiplied in the presence of the gene UCP1. | |
| PPARG | 601487 | The ancestral gene is not suitable for contemporary foods such as refined foods (flours and sugars) or processed and saturated fats that promote fat formation and insulin resistance. This gene also complicates the burning of calories. In addition, this gene is the main target of one of the antidiabetic drugs, a good knowledge of this gene allows a personalized treatment | |
| ACE | 106180 | This gene regulates blood pressure through the level of sodium in the kidneys and also promotes fat formation, so salt intake not only promotes hypertension, it also causes overweight and obesity. | |
| IL1B | 147720 | It promotes chronic inflammation and, associated with the action of the next gene, is directly related to the control of body fat especially in young people. It acts on the regulation of fat formation, the control of intake and energy expenditure and therefore on the impact of obesity. | |
| IL1RN | 147679 | It modifies the function of the immune system, promoting inflammation of fat, this being closely related to the development of obesity. Its action is reinforced by that of the previous gene, increasing the amount of total fat. | |
| IL6 | 147620 | It causes a chronic low-grade inflammation of adipose tissue, induces insulin resistance because it alters its receptor and promotes the development of type 2 diabetes (adult). | |
| TNFa | 191160 | It promotes inflammation of the fatty tissue and modifies the insulin receptor and leptitis, causing resistance to these hormones due to the dysfunction of its receptor. | |
| FABP2 | 134640 | It allows a better absorption of dietary fat in the intestine and alters its oxidation, promoting insulin resistance and increasing the risk of atherosclerosis | |
| ADIPOQ | 605441 | It induces insulin resistance that hinders carbohydrate metabolism and promotes the development of obesity and type 2 diabetes. | |
| IRS1 | 147545 | It causes insulin resistance and therefore a high risk of diabetes because it directly affects the insulin receptor. |