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Obesity and Diabetes

Learn how genetics influence your diet and your risk of type 2 diabetes.

With this study, your nutritionist will be able to prepare a personalized diet just for you with the greatest possible guarantee of success. Genes related to your metabolism, the capacity to burn fat, obesity, type 2 diabetes, inflammation in adipose tissue are analysed to detect your risks and be able to take preventive measures.

500M

It is estimated estimate that by 2018 there are more than 500 million cases of type 2 diabetes worldwide

and the number will continue to grow in the coming years.⁽¹⁾

39%

39% of the world's adult population is overweight

and 13% is obese, according to 2016 data.⁽²⁾

Obesity

Overweight and obesity are major risk factors

for a number of chronic diseases, including diabetes, cardiovascular diseases and cancer.⁽³⁾

+ risk

Obesity is associated with an increased risk of developing multiple types of cancer.

It is estimated that up to 20% of all cancers are caused by obesity.⁽⁴⁾

_{(1) Source: https://diabetes.diabetesjournals.org/content/67/Supplement_1/202-LB}
_{(2) Source: World health organization}
_{(3) Source: World health organization}
_{(4) Source: Revista española de cardiología}

Obesity and Diabetes

A number of genes related to central intake control, thermogenesis regulation, pro-inflammatory processes in adipose tissue and development of insulin resistance are analyzed.
A genetic counsellor approved by medmesafe will accompany you before and after the analysis by video consultation.

3 weeks

Spain

Saliva

PCR

Counting from the reception of the sample in the laboratory.

Only available in Spain at the moment

Collection of saliva.

These genes are analyzed by the PCR multiple amplification technique, and the reaction products are studied by mini-sequencing and subsequent capillary electrophoresis.
These molecular biology techniques are commonly used in the molecular genetics laboratory and have a high sensitivity and specificity when using specific primers for each polymorphism that is analysed. The reliability of the genetic studies is close to 100%, and in the laboratory we follow all the quality processes, audited by national and international entities.

Nutrigenetics examines how genetic variation affects the response of an organism to a given diet, evaluating the risks and benefits of specific diets and dietary components and formulating “personalized nutrition” recommendations

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155887/

How does it work?

Select desired analysis and a specialist, then you have a video-consultation.
Receive a sample collector kit at home that will be picked up by a courier.
One of our partner labs makes the analysis.
Your healthcare professional presents your results via videoconference.

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What is this analysis for?

To know the genetic load of these common multifactorial diseases and to weigh them in relation to environmental factors.
So that you know the mechanisms that produce obesity, diabetes or cardiovascular disease in each case to provide personalized treatments.
So that you can apply preventive measures in you or your family in case of risk.

Should you do it?

If you have a family history:

You have first-degree parents who suffer from obesity or overweight.
You have a family history of adult diabetes.

If you suffer from OBESITY:

Severe obesity and / or early origin (childhood / adolescence).
You have been on several diets without losing weight or have observed the yo-yo effect.
You have eating disorders: satiety or anxiety problems.
You can't burn calories despite exercising.
You gain weight despite a healthy lifestyle.

If you suffer from DIABETES:

You have difficulty metabolizing carbohydrates.
You have high levels of glucose, insulin or glycosylated hemoglobin.
Carbohydrates make you gain weight easily.
You suffer from obesity (mainly abdominal obesity) and want to prevent the development of diabetes.

If you want to improve your quality of life.

GEN	OMIM or reference	FONCTION	RELATED DISEASE AND GENE TYPE
MC4R	155541 601665	It is related to eating behavior because it reduces satiety and increases appetite, which promotes overweight and obesity	OBESITY AND DIABETES :ECONOMIC GENES
FTO	610966	It reduces satiety and increases appetite for high-calorie foods such as fats and sugars. It also lowers the production of heat of the body, thus promoting the storage of energy in the form of fat
BDNF	113505 607499	It promotes the storage of fat in stressful situations, it is found more frequently in women.
UCP1	113730	It regulates the action thyroid hormone responsible for burning calories in the form of heat, although at rest this pendant unites physical activity. If this function is slowed down, the body accumulates fat.
UCP3	602044	It is involved in the production of heat through the thyroid hormone and also plays a role in the burning of calories on physical activity. These are malfunctions that promote overweight and obesity
ADRB2	109690 601665	It regulates the response of the body to stress by translating it into a feeling of hunger and responds by storing energy in the form of fat.
ADRB3	109691	It responds to stress by interpreting it as hunger, which promotes overweight and obesity. It is also associated with insulin resistance and metabolic syndrome. This gene has its effects multiplied in the presence of the gene UCP1.
PPARG	601487	The ancestral gene is not suitable for contemporary foods such as refined foods (flours and sugars) or processed and saturated fats that promote fat formation and insulin resistance. This gene also complicates the burning of calories. In addition, this gene is the main target of one of the antidiabetic drugs, a good knowledge of this gene allows a personalized treatment
ACE	106180	This gene regulates blood pressure through the level of sodium in the kidneys and also promotes fat formation, so salt intake not only promotes hypertension, it also causes overweight and obesity.
IL1B	147720	It promotes chronic inflammation and, associated with the action of the next gene, is directly related to the control of body fat especially in young people. It acts on the regulation of fat formation, the control of intake and energy expenditure and therefore on the impact of obesity.
IL1RN	147679	It modifies the function of the immune system, promoting inflammation of fat, this being closely related to the development of obesity. Its action is reinforced by that of the previous gene, increasing the amount of total fat.
IL6	147620	It causes a chronic low-grade inflammation of adipose tissue, induces insulin resistance because it alters its receptor and promotes the development of type 2 diabetes (adult).
TNFa	191160	It promotes inflammation of the fatty tissue and modifies the insulin receptor and leptitis, causing resistance to these hormones due to the dysfunction of its receptor.
FABP2	134640	It allows a better absorption of dietary fat in the intestine and alters its oxidation, promoting insulin resistance and increasing the risk of atherosclerosis
ADIPOQ	605441	It induces insulin resistance that hinders carbohydrate metabolism and promotes the development of obesity and type 2 diabetes.
IRS1	147545	It causes insulin resistance and therefore a high risk of diabetes because it directly affects the insulin receptor.