Cardiovascular Risk

elige tu test genético

What do we offer?

  • icono de laboratorioDetection of genes involved in predisposition to : Dyslipidemia - Acute myocardial infarction - Arterial hypertension - Venous thromboembolism
  • icono de asesoramiento facultativoCounselling by a specialist before and after the analysis
  • icono de la muestraSample type: Collection of saliva through an oral swab
  • icono de tiempoResults in: 14 days*
  • 735 **
  • * Labour days counting from reception of the sample at the laboratory.
    ** Shipping charges included in peninsular Spain. Not included in Islands.

More information: +34 911 284 591
elige tu test genético
More information: +34 911 284 591

Why should you request this service?

What is the purpose of this analysis?

  • To prevent heart disease. At least 80% of premature deaths due to heart disease and stroke could be prevented through regular predictive studies that prevent the need for lifestyle changes, healthy eating and regular physical activity.

  • To know the risk of suffering from high blood pressure and thus having the opportunity to prevent the appearance of symptoms by changing environmental factors and minimize the risk of developing associated pathologies in the kidneys, brain or heart. It is particularly relevant to do this analysis if you have parents with hypertension to prevent the onset of the disease.

  • To indicate to you the risk of suffering from ischemic heart disease, thus having the possibility of preventing its appearance with healthy lifestyles and personalized treatments.

  • This analysis also allows you to know the risk of venous thrombosis, thus giving you the possibility of preventing its appearance by changing environmental factors (eating habits, administration of anticoagulants, exercise...). The result also helps prevent thrombophilia in family members.

Should you do it?

  • You have a family history of dyslipidemia, diabetes, hypertension, obesity, venous thrombosis, arterial thrombosis, embolism, etc.

  • You are a man over 50 years old.

  • You do not have any family history:

    • You suffer from diabetes, high blood pressure, obesity.

    • You are taking oral contraceptives.

    • You have had thrombosis during your pregnancy.

    • You have had several abortions.

    • You have children with NTD (neural tube defect).

    • You are pregnant and have IUGR, (intrauterine growth restriction) thrombophlebitis or placental thrombosis.

    • You face prolonged immobility (prolonged postoperative and lower limb pathologies).

    • You have varicose veins.

More information: +34 911 284 591
More information: +34 911 284 591

How does it work?

  1. elige tu test genético
    Select desired analysis and a specialist, then you have a video-consultation.
  2. frotis bucal para análisis
    Receive a sample collector kit at home that will be picked up by a courier.
  3. instrucciones de uso
    One of our partner labs makes the analysis.
  4. instrucciones de uso
    Your healthcare professional presents your results via videoconference.
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To go further:

Subtitles available in both English and French
More information: +34 911 284 591
More information: +34 911 284 591

additional information

  • What are the genes studied and what does it mean?
      ACE 106180 Diseases of the coronary arteries and cardiovascular diseases/td> Risk of acute myocardial infarction
      Risk of hypertension
      Coronary changes
      APOA5 606368 Risk of hypertriglyceridaemia
      APOC3 107720 Risk of hypertriglyceridaemia
      APOE 107741 Cardiovascular diseases
      ADRB2 109690 Metabolic syndrome
      Risk of hypertension
      GNB3 139130
      Risk of progression to more severe hypertension
      NOS3 163729 Preeclampsia, Coronary disease Risk of hypertension
      F2 176930
      Thrombophilia Risk of thromboembolism
      F5 612309
      Thrombophilia due to resistance to activated protein C Thrombophilia risk due to factor V Leiden
      FGB 134830
      Thrombolia Increased risk of venous thromboembolism and cardiovascular disease
      MTHFR 607093
      Risk of cardiovascular disease and neurodegenerative diseases due to hyperhomocysteinemia Risk of thromboembolism
      SERPINE1 173360
      Thrombophilia Increased risk of thrombotic troubles
  • How to interpret the results?
      Gene ACE: POLYMORPHISME IVS16-407ins(289nt)
      Gene APOA5: POLYMORPHISME c.-73-571C>T
      Gene APOC3: POLYMORPHISME c.*40G>C
      Gene ADBR2: SNP p.Gly16Arg (rs1042713)
      Gene GNB3: SNP c.825C>T (COSM147403)
      Gene NOS3: SNP p.Glu298Asp (rs1799983)
      Gene F2: MUTATION c.20210G>A
      Gene F5: MUTATION c.1691G>A
      Gene FGB: SNP c.-455G>A (rs1800790)
      Gene MTHFR: MUTATIONS c.677C>T Y c.1298A>C
      Gene SERPINE1 (PAI-1): POLYMORPHISME c.-675_4G/5G
      No genetic variants predisposing to the disease have been detected.
      Increased risk Moderate risk
  • Sensitivity and Specificity

      The analysis of this gene is carried out using the PCR (Polymerase Chain Reaction) technique. Moreover, the results are studied by direct sequencing and subsequent capillary electrophoresis. These molecular biology techniques are commonly used in the field of molecular genetics and exhibit high sensitivity and specificity when using specific primers for each analyzed polymorphism. The reliability of our genetic studies is close to 100%, we apply quality processes certified by competent national and international organizations.

  • Sources
    • Nichols M, et al. European Cardiovascular Disease Statistics 2012. European Heart Network, Brussels and European Society of Cardiology. Sophia Antipolis. 2012.
    • Cordero, A., et al. Situación actual de la dislipemia en España: La visión del cardiólogo. Revista Española de Cardiología Suplementos, vol. 15 issue Supl.A (2015) pp: 2-7 Published by Elsevier; doi: 10.1016/S1131-3587(15)70117-2.
    • Cambien, F., et al. Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy study. Am. J. Hum. Genet. 43: 774-780, 1988
    • Ding Y, Zhu MA, Wang ZX, Zhu J, Feng JB, Li DS. Associations of polymorphisms in the apolipoprotein APOA1-C3-A5 gene cluster with acute coronary syndrome. J Biomed Biotechnol. 2012;2012:509420.
    • Evans D, Bode A, von der Lippe G, Beil FU, Mann WA. Cerebrovascular atherosclerosis in type III hyperlipidemia is modulated by variation in the apolipoprotein A5 gene. Eur J Med Res. 2011 Feb 24;16(2):79-84.
    • Saeed Mahmood, M, et al. Association of the angiotensin-converting enzyme (ACE) gene G2350A dimorphism with essential hypertension. J Hum Hypertens. 2003 Oct;17(10):719-23. OI:10.1038/sj.jhh.1001600.
    • Luft FC. Twins in cardiovascular genetic research. Hypertension. 2001 Feb;37(2 Pt 2):350-6.
    • Seidlerová J, Filipovský J, Mayer O Jr, Kučerová A, Pešta M. Association between endothelial NO synthase polymorphisms and arterial properties in the general population. Nitric Oxide. 2015 Jan 30;44:47-51
    • Vecoli C. Endothelial nitric oxide synthase gene polymorphisms in cardiovascular disease. Vitam Horm. 2014;96:387-406
    • Takeuchi F, Yamamoto K, Katsuya T, Sugiyama T, Nabika T, Ohnaka K, Yamaguchi S, Takayanagi R, Ogihara T, Kato N. Reevaluation of the association of seven candidate genes with blood pressure and hypertension: a replication study and meta-analysis with a larger sample size. Hypertens Res. 2012 Aug;35(8):825-31
    • Hager A, Bildau J, Kreuder J, Kaemmerer H, Hess J. Impact of genomic polymorphism on arterial hypertension after aortic coarctation repair. Int J Cardiol. 2011 Aug 18;151(1):63-8.
    • Guo X, Cheng S, Taylor KD, Cui J, Hughes R, Quiñones MJ, Bulnes-Enriquez I, De la Rosa R, Aurea G, Yang H, Hsueh W, Rotter JI. Hypertension genes are genetic markers for insulin sensitivity and resistance. Hypertension. 2005 Apr;45(4):799-803.
    • Varga, E. A., et al. Management of inherited thrombophilia: guide for genetics professionals. Clin. Genet. 81: 7-17, 2012.
    • Grimaudo, V., et al. Hypofibrinolysis in patients with a history of idiopathic deep vein thrombosis and/or pulmonary embolism.
    • Kathiresan S1, Yang Q, Larson MG, Camargo AL, Tofler GH, Hirschhorn JN, Gabriel SB, O'Donnell CJ. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1405-12.
    • Online Mendelian Inheritance in Man, OMIM®. McKusick- Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD), {24/04/2018}. World Wide Web URL: https://omim.org/
More information: +34 911 284 591
More information: +34 911 284 591

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